Such a hypothesis is plausible as it is known that some human molecules were evolved to escape from the parasite recognition, for example majority of west Africans do not express the Duffy Antigen Receptor for Chemokines (DARC), a receptor for the other human malaria parasite Plasmodium vivax, on their RBC and became resistant against this malaria parasite species [28, 29]. This evidence concerns the gene ACKR1 and malaria.