Moreover, OPG, as well as RANKL, are expressed within the failing myocardium in both experimental and clinical heart failure (HF), and strong immunostaining of these molecules has also been found within atherosclerotic carotid plaques as well as in thrombus material obtained at the site of plaque rupture during myocardial infarction (MI) [10]. This evidence concerns the gene TNFRSF11B and myocardial infarction.