In the +/- 20 kb region surrounding PSMD2, a genotyped missense SNP rs2178403 (A/G, Met/Val), located in gene EIF4G1 and excluded from gene-based analyses due to its high LD (r2 = 0.93) with SNP rs1879244 (Table 2), was associated with diabetes risk, with a p-value smaller than that of the nine SNPs from the best model (p = 8.0 x 10−5). The gene discussed is EIF4G1; the disease is diabetes mellitus.