Genes involved in the β-catenin destruction complex may influence susceptibility to type 2 diabetes, given the critical role this complex plays in Wnt signal transduction with the resulting downstream effects on diabetes locus TCF7L2. AA as well as European individuals may be affected, considering that the TCF7L2 / diabetes association is seen across racial groups. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.