In vitro, melanoma cell lines are also able to adhere to endothelial cells in a process involving αvβ3 integrin [42, 43], α4β1-integrin, endothelial VCAM-1, Lu-ECAM-1, as well as the chemokines, including CXCL12 [44, 45]. Here, CXCL12 is linked to melanoma.