While the GPIIb-IIIa receptor complex is platelet-specific, the GPIIIa (ß3 integrin) subunit also associates with another α subunit to form the vitronectin receptor (αvß3 integrin), expressed by endothelial cells, osteoclasts, and other cells including some tumor cells (reviewed in [47]). Here, ITGB3 is linked to neoplasm.