Given that ID4 expression inversely correlates with CRPC compared with that in hormone‐naïve prostate cancer (Patel et al., 2014), we primarily focused our attention on the LNCaP and stable LNCaP(−)ID4 cell lines, which mimics decreased ID4 expression in PCa (Knowell et al., 2013; Patel et al., 2014). The gene discussed is ID4; the disease is posterior cortical atrophy.