In addition, twelve loci in nine genes (A1CF, PDZK1, GCKR, ABCG2, SLC2A9, TRIM46, HNF4G, SLC17A1 and SLC17A4) were found to influence the risk of gout (all P < 0.05) (Table 1). The gene discussed is PDZK1; the disease is gout.