HNF4G is a novel gout-associated gene associated with the pathogenesis of gout (OR = 1.28, PFDR = 1.08E-03), and two other genes, A1CF and TRIM46, were identified to be associated with susceptibility to gout in the Chinese population for the first time (rs10821905 in A1CF: OR = 1.61, PFDR = 1.57E-03; rs4971101 in TRIM46: OR = 1.37, PFDR = 3.25E-04; rs2070803 in TRIM46: OR = 1.22, PFDR = 0.031). This evidence concerns the gene HNF4G and gout.