Six genes (A1CF, ABCG2, SLC2A9, TRIM46, SLC17A1 and SLC17A4) exhibited effects on the development of gout from hyperuricemia in males (all P < 0.05), but none of them exhibited such effects in females (all P > 0.05) (Table 2). The gene discussed is TRIM46; the disease is hyperuricemia.