CPEB1 and neoplasm: But the current study suggests that miR-101 may be a core unit, and MRE of miR-101 is an important functional sequence for the crosstalk among CASC2c, miR-101 and its target gene CPEB1. Low expression of miR-101 is one of the reasons for high expression of CPEB1, whereas the high expression of CASC2c may account for miR-101 low expression and overexpression of CPEB1, whereas ectopic miR-101 expression mediated tumor suppression of shCASC2c in astrocytoma.