MYCN and neuroblastoma: Targeting rapid proliferation in MYCN-amplified neuroblastoma cells by downregulating genes indispensable for cell cycle progression has previously been shown to elicit cell cycle arrest and cell death, and is considered a promising strategy to block the oncogenic effect of MYCN amplification on cell cycle.33 The strong phenotype produced by HDAC11 depletion in MYCN-amplified neuroblastoma cell lines supports this approach.