We next turned to two independently existing whole-genome expression profiles from 47630 and 886 primary neuroblastomas to investigate the correlation between overall and event-free survival in patients with tumors expressing CCNE1, CENPA, CENPE, DLGAP5, KIF14, KIF23, MAD2L1, RACGAP1 or UHRF1. High-level expression of each single gene strongly correlated with unfavorable overall and event-free patient survival in the entire cohort and in the patient subgroup with tumors lacking MYCN amplifications (Table 1; Supplementary Table S3). The gene discussed is MAD2L1; the disease is neuroblastoma.