Expression of the FLAG-tagged 347 amino acid open reading frame in human embryonic kidney 293 cells, demonstrated the protein primarily localizes to the nucleus and is capable of deacetylating a synthetic peptide derived from histone H4.24 Subsequent studies in recent years have shed light on the role of HDAC11 in health and disease.25 Here we aimed to assess the significance of HDAC11 expression for neuroblastoma biology, which is as yet unknown. This evidence concerns the gene HDAC11 and neuroblastoma.