CD82 and gastric neoplasm: Higher levels of LAMC2 are in most of the malignant tumors and correlate with poor overall survival and metastasis, as a therapeutic target for human cancers,19, 20 whereas CD82 (also called KAI-1), as a metastasis suppressor gene, is downregulated in cancers.21 These data support our findings that enhanced LAMC2 and decreased CD82 in GC cells are critical for gastric tumor invasion and metastasis.