In line with this, knockdown of CD82 expression by sh/CD82 or miR-197 in Drosha-silenced MGC-803 cells resulted in the increased expression of p-EGFR, p-ERK1/2 and MMP7 (Figure 6g), which rendered the tumor cells with a marked invasive potential (Figure 6i). The gene discussed is MAPK3; the disease is neoplasm.