DROSHA and cancer: It is inseparable that the role of aberrant Drosha in the tumor progression may be dependent on miRNAs, which have referred to tumor initiation and development as oncogenes or tumor suppressor genes through negative regulation of hundreds of target genes at the post-transcriptional level.7 Dysregulated miRNAs are detected in different kinds of cancers, including colorectal carcinoma,8 breast cancer9 and GC,4 and involved in tumor pathology, diagnosis, treatment, prognosis and other processes.