LAMC2 could colocalize with EGFR in the ATC cells12 and CD82 suppresses the phosphorylation of EGFR in EGF- and HGF-dependent manner in Hepa1–6 cells,13 indicating that the aberrant LAMC2 and CD82 may be involved in tumor cell invasion through the activity of EGFR and its downstream signaling in GC cells. This evidence concerns the gene EGF and gastric cancer.