For example, the downregulated Drosha proteins were detected in gallbladder cancer and the decreased Drosha was used as indicators of poor prognosis in gallbladder cancer patients.5 In contrast, the increased Drosha expressions were observed in non-small-cell lung cancer,6 which was closely related to the pathological stage, tumor metastasis and worse prognosis. The gene discussed is DROSHA; the disease is non-small cell lung carcinoma.