Higher levels of LAMC2 are in most of the malignant tumors and correlate with poor overall survival and metastasis, as a therapeutic target for human cancers,19, 20 whereas CD82 (also called KAI-1), as a metastasis suppressor gene, is downregulated in cancers.21 These data support our findings that enhanced LAMC2 and decreased CD82 in GC cells are critical for gastric tumor invasion and metastasis. The gene discussed is LAMC2; the disease is cancer.