They include lncRNA growth arrest-specific 5 (GAS5), which is a known tumor suppressor that promotes growth arrest and/or apoptosis in multiple cell types.33, 34 Overexpression of lncRNA GAS5 was shown to reduce invasion in human melanoma cells,34 while knockdown of lncRNA GAS5 was reported to abolish cell cycle arrest at G1 phase in stomach cancer.35 We thus selected lncRNA GAS5 for further study. This evidence concerns the gene GAS5 and melanoma.