It was previously reported that the signaling axis consisting of laminin-332, integrin-α6β4, and EIF4E enhances the expression of VEGFs.21 Laminin-332 and integrin-α6β4 are also known to be overexpressed in the margin between tumor and fibrotic stoma, where compression is induced by tumor growth in breast IDC.17LAMC2 encodes the gamma subunit of laminin-332, ITGA6 and ITGB4 encode the subunits of integrin-α6β4, and EIF4E encodes the EIF4E protein. Here, ITGB4 is linked to neoplasm.