Additionally, numerous proteins including alpha 2-antiplamin (A2AP), alpha 1-antichymotrypsin (AACT), complement C1r (C1R), complement factor B (CFAB), complement component 4 A (CO4A) were strongly associated with AD and FA in the middle cerebellar peduncle in controls, but not in the MA or MAP groups. This evidence concerns the gene SERPINA3 and Alzheimer disease.