Gene transcripts encoding structural and functional genes such as myosin heavy chain isoforms (MYH1, MYH2, MYH4), and laminins (LAMB3) were highly upregulated in skeletal muscle from T2D patients, whereas genes encoding proteins involved in mitochondrial biogenesis (PPARGC1A) and respiration (COX6A2) were suppressed. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.