BIRC5 and central nervous system cancer: We and others showed in this study, and other studies [57–59], that the survivin promoter in comparison to other promoters may represent an optimal radiation inducible promoter and provide compelling data to suggest that radiation, a mainstay of glioma therapy, further improves survivin-mediated adenoviral gene expression in targeted cells, which is a finding that might have significant implications for patients who may one day be treated with this virus and subsequently receive radiotherapy.