While regulation of cell proliferation is mostly mediated by activation of the p38- and MEK-driven MAPK signaling cascades, most of the published work suggests a more prominent role of AXL in the PI3K/AKT/mTOR and JAK/STAT pathways in tumor cell survival [1••, 2, 10, 64] (Fig. 1). Here, AKT1 is linked to neoplasm.