CYBA and chronic granulomatous disease: Autosomal recessive CGD (AR-CGD) is mostly caused by defects in 1 of the 3 components of NADPH oxidase: p47phox (encoded by NCF1 gene, localized on chromosome 7q11.23), p22phox (encoded by CYBA gene, localized on chromosome 16: 16q24), and p67phox (encoded by NCF2 gene, localized on chromosome 1q25), accounting for about 20%, 5%, and 5% CGD patients, respectively.