SIAH1 and neurodegenerative disease: In addition, GAPDH has been suggested to have high affinity for AD-associated proteins, including β-amyloid, β-amyloid precursor protein, and tau [25], and to be involved in the NO/GAPDH/Siah-1 apoptotic cell death cascade [26], particularly in neuronal cell death associated with neurodegenerative diseases [25, 27].