Moreover, the results of PPI analysis indicated that TBI-induced cognitive impairment is a multifactorial process of pathological progress that involves various proteins that interact with each other including the SPARCL1-CALM-ACTC1-TUBA4A-GAPDH-LPL-SHBG-SERPINA6 network. The gene discussed is TUBA4A; the disease is Cognitive impairment.