NO is known for its antiproliferative and cytotoxic effects in glioblastoma cells at high concentrations and its impact on migration, invasion and angiogenesis in various tumor cells at low doses.28,29,38 JS-K is an arylating agent designed to release nitric oxide upon reaction with glutathione in the presence of glutathione S-transferase, an enzyme overexpressed in cancer cells.25,28,39 Thus, JS-K application in GBM cells allows a cell type-specific intracellular NO release. Here, HPGDS is linked to cancer.