NFKB1 and glioblastoma: The impact of high dose JS-K was described by our group as dose- and time-dependent concerning the inhibition of proliferation and induction of cell death.28,29,40 NO induces DNA double-strand breaks and post-translational modifications of proteins, such as S-nitrosylation of NFκB resulting in activation of caspase-dependent and caspase-independent pathways.31,32,38 In previous studies we observerd the strongest cellular effects in glioblastoma cells after 48 h of JS-K treatment.