C7 and recessive dystrophic epidermolysis bullosa: Our target cell population was carefully considered due to the fact that fibroblasts competent for C7 protein expression have utility for localised therapy in RDEB.49 Given the comparatively diminished proliferation capacity and rate of fibroblasts compared with iPSCs, we also attempted gene correction in iPSCs due to the fact that HDR occurs in late S and G2.50,51 Surprisingly, we were unable to achieve gene correction in this patient’s iPSCs, while we obtained 12 corrected fibroblast clones.