Specific methylation signatures of NAFLD-related genes (i.e., nuclear respiratory factor 1 [NRF1], heat shock transcription factor 1 [HSF1], and estrogen related receptor alpha [ESRRA]) were clearly distinct after the bariatric procedure, both in gene ontology and transcription factor binding site analyses. The gene discussed is ESRRA; the disease is metabolic dysfunction-associated steatotic liver disease.