Results of our study suggest that high dose SM extract showed significant effects in reducing hyperuricemia and MSU crystal-induced inflammation; such activity is probably due to suppress the production of proinflammatory cytokines (TNF-α and IL-1β) and the neutrophil accumulation (MPO), lower lipid peroxidation (MDA), and increase antioxidant status (SOD). Here, SOD1 is linked to hyperuricemia.