Most interestingly, this variant was associated with a 46% decreased risk of myocardial infarction, confirming the previous report by Lucthefeld et al. Recently, Wonnerth et al. have shown that carriers of the 148Arg allele had higher circulating levels of soluble gp130 (sgp130); interestingly, they were able to replicate these results in two different cohorts [44]. The gene discussed is IL6ST; the disease is myocardial infarction.