Of special concern is the supporting evidence that the repression of Beta-2-microglobulin (beta-2-M), MHC class I alpha chain and MHC class II, DR alpha at day 7 post-infection and MHC class I alpha chain and MHC class II Alpha chain A alpha chain expression at day 50 post-infection in the abomasal tissue of sheep experimentally infected with H. contortus employing Illumina RNA-Seq technology (unpublished data). The gene discussed is B2M; the disease is infection.