Results from our proteomics study demonstrated that aldehyde dehydrogenase 1A1 (ALDH1A1) protein expression was deficient in primary dermal fibroblasts from Gorlin syndrome patients (GDFs), as compared with primary normal human dermal fibroblasts (NHDFs) used as controls. This evidence concerns the gene ALDH1A1 and nevoid basal cell carcinoma syndrome.