HeLa, CGL3 and SiHa carcinoma cells as well as HCE16/3 immortalized cells were investigated for S100P expression. DNA methylation was inhibited by 5-aza-dC in S100P-negative cell lines CGL1 and Caski and the SP100 expressing SiHa cells. Suppression subtractive PCR between two HeLa cell lines with different tumerigenic capacity. Here, S100P is linked to carcinoma.