PDIA3 and cancer: PDIA3 was overexpressed in 73% of cancers. PDIA3 expression was significantly higher in patients with AD compared with SCC. Staining was intense in AD with a penetration depth greater than half of the cervical stroma. High expression was associated with low overall survival and recurrence-free survival (RFS) rates. Patients exhibiting both high PDIA3 expression and lymph node metastasis displayed poorer outcomes than other patient groups. Knockdown of PDIA3 in HeLa cells decreased cell invasiveness and inhibited lung metastasis in a xenograft mouse model.