Patients with GC and CC genotypes and C allele exhibited a lower degree of differentiation and a higher degree of malignancy. Early cervical cancer, lymphatic metastasis and poorly differentiated carcinomas exhibited higher MIF levels in serum. Moreover, patients with the CC genotype exhibited higher MIF serum concentration, which could increase the risk of early stage cervical cancer and lymphatic metastasis. The gene discussed is MIF; the disease is cervical cancer.