The transcription of investigated genes was promoted by UA in RPE cells but antagonized in skin melanoma cells, indicating that UA-mediated AMPK-(PGC-1α) signaling enhances metabolic gene transcription in RPE cells while inhibiting the transcription in skin melanoma cells by eliciting AKT-inactivated PGC-1α expression, as indicated by the downstream effecter, NF-κB (Figure 3) [18,124]. The gene discussed is NFKB1; the disease is cutaneous melanoma.