Upon investigating lung cancer cell lines with different invasive and metastatic capabilities (CL1-0 and CL1-5 cells), retinal dehydrogenase I (ALIA1), peroxiredoxin-I (PRDX1) and nidogen-1 (NID-1) were found to be higher in CL1-0 and collagen alpha-1 (VI) chain (COL6A1), metalloprotease inhibitor 1 (TIMP1), urokinase-type plasminogen activator (uPA) and alpha-1-antitrypsin (AAT) were higher in CL1-5 [28]. Here, PLAU is linked to lung cancer.