SERPINH1 and neoplasm: An interesting method (consisting in the combination of 2DE and highly sensitive differential gel electrophoresis (DIGE) saturation labeling for the analysis of limited amounts of microdissected material), established by Poschmann et al. [77] to monitor protein changes in SCC tumor progression, revealed that heat-shock protein 47 (HSP47) and a group of cytokeratins were significantly co-regulated in SCC.