Although caution should be placed when depletion/enrichment strategies (which can result in a loss of less abundant proteins) are applied, the isolation of N-linked glycosylated peptides confirmed a few markers (i.e., SP-A, a marker also for COPD) and found novel potential candidates, including periostin, multimerin-2, CD-166 and lysosome-associated membrane glycoprotein-2 (LAMP-2). This evidence concerns the gene LAMP2 and chronic obstructive pulmonary disease.