In colon cancer, a combination of six serum markers including CEA, CYFRA21-1, ferritin, osteopontin (OPN), seprase and anti-p53 autoantibody showed a comparable sensitivity to fecal immunochemical testing with 68.9% versus 72.7% at 98% specificity [34]. This evidence concerns the gene SPP1 and malignant colon neoplasm.