PDCD4 also represses theinvasion and intravasation of CRC cell lines in a chick embryo metastasis model(Asangani et al., 2008); there isevidence that PDCD4 executes this function by repressing the pro-metastaticurokinase receptor (uPAR) (Leupold et al.,2007). The gene discussed is PDCD4; the disease is colorectal carcinoma.