Forexample, miR-135a/b miRNAs, which are overexpressed in CRC, are able todirectly target APC, leading to the upregulation of Wntsignaling (Nagel et al., 2008).MiR-135a/b is also predicted to target and inhibit secretedfrizzled-related protein 4 (SFRP4), which binds and represses extracellular Wntproteins (Kawano and Kypta,2003). This evidence concerns the gene APC and colorectal carcinoma.