MiR-17 appears topromote CRC tumorigenesis, evident in studies showing that it suppresses apoptosisand cell cycle arrest, increases migration, and drives tumor xenograft growth of CRCcell lines (Ma et al., 2012).Further analysis has revealed that miR-17 directly represses the cell cycleregulator and RB-family member P130 (RB transcriptional co-repressor like 2,RBL2), a tumor suppressor that also negatively regulatesβ-catenin levels and Wnt signaling (Ma et al., 2012). Here, RB1 is linked to neoplasm.