In mice, mutations in thecanonical CRC tumor suppressors Pten or Trp53in the context of Apc loss greatly enhance the upregulation ofmiR-135b, with phosphoinositide 3-kinase (PI3K) and downstream FOXO1 and FOXO3Atranscription factors confirmed as regulators of miR-135b (Valeri et al., 2014). This evidence concerns the gene APC and colorectal carcinoma.