PTEN and colorectal carcinoma: MiR-17 also targets and inhibits PTEN(Fang et al., 2014) and RHOE(RND3), which encodes a GTP-binding protein (without GTPaseactivity) that is reduced in CRC and can repress tumor cell invasion (Thuault et al., 2016), promotecontact inhibition (Hernández-Sánchez et al., 2015) and downregulate Notchsignaling (Tang et al., 2014b;Zhu et al., 2014b).