The 7 identified miRNAs might be involved in several pathways, including T2DM, renal cell carcinoma, AMPK signaling pathway, and PI3K-Akt signaling pathway; however, the detailed function associated with these miRNAs in AOE therapy needs further investigation and the target genes of miRNAs need further validation through additional studies. This evidence concerns the gene AKT1 and renal cell carcinoma.