One study showed that when shear stress is applied to endothelial cells there is an increase in ETB receptors, c-jun, and AP-1 [33] and a study using a rodent model of glaucoma also showed involvement of AP-1 and C/EBPβ in the upregulation of ETB receptors [29], although the mechanotransduction pathways have not been fully elucidated. Here, JUN is linked to glaucoma.