Moreover, both robustly expressed DKK3 and weakly expressed β-catenin proteins were found predominantly in the cytoplasmic compartment of normal adrenal cortex (Fig. 1b; b-g), while increased β-catenin levels were found both in the cytoplasm and the nuclei of ACC cells (Fig. 1b; i-n). Here, DKK3 is linked to adrenal cortex carcinoma.