NPM1 and acute myeloid leukemia: Ley et al. (2008) performed the first AML WGS study on one Caucasian woman with the cytogenetically normal AML subtype M1 and reported non-synonymous single nucleotide variants (nsSNVs) in eight genes (i.e., CDH24, PCLKC, GPR123, EBI2, PTPRT, KNDC1, SLC15A1, and GRINL1B) and insertions in the coding regions of the FLT3 and NPM1 genes [7].