Although pooling findings from the six trials (EXAMINE, SAVOR-TIMI53, ELIXA, LEADER and SUSTAIN-6) showed incretin-based agents were not associated with any or severe hypoglycemia (RR = 1.05, 95% CI 0.96–1.15 for any hypoglycemia, RR = 0.97, 95% CI 0.74–1.26 for severe hypoglycemia, Fig. 4), DPP-4Is increased the risk of both types of hyperglycemia and GLP-1As decreased risk for severe hypoglycemia (Fig. 4b). The gene discussed is GCG; the disease is Hypoglycemia.