To date, the pathophysiology and molecular mechanisms underlying these associations are not fully understood, although several hormonal systems—have been studied to some extent, and a leptin-cytokine cross talk has been observed in breast cancer [26] The role of leptin and sPLA2-IIA in the initiation and metastasis of tumors has been documented and reviewed, and here we pay attention to both proteins as emerging candidate molecules linking obesity and inflammation in glioma tumors [6,8,21]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.