NLRP3 and metabolic dysfunction-associated steatohepatitis: Since in a previous study some of us reported that MVs production associated with NASH required caspase-3 activity and was appreciably decreased in caspase-3 knock out (caspase-3-/-) mice fed with the MCD diet [22], here we evaluated whether the lack of MVs production in caspase-3-/- animals might affect NLRP3 responses.