In particular, the transition from NAFLD to NASH associates with NLRP3-inflammasome activation and an increased expression of inflammasome-related components, including apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC), caspase-1 (CASP‐1) and pannexin [28–32]. The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatohepatitis.