Along these lines, one of the most recently identified contributor to the cross talk between hepatocytes and inflammatory macrophages is represented by the multiprotein platform complex nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, whose activation has been suggested to play a crucial role in the progression of NAFLD [28]. Here, NLRP3 is linked to metabolic dysfunction-associated steatotic liver disease.