The VLF had a positive association with systolic blood pressure (B 0.01, 95% confidence interval [CI] 0.00 ~ 0.012, p = 0.027) during hemodialysis, but had a negative association with the oral anti-diabetic drug (OAD) (B -0.95, 95% CI -1.30 ~ -0.61, p < 0.001), the subcutaneous insulin therapy (B -1.36, 95% CI -1.77 ~ -0.95, p < 0.001) and the peripheral arterial disease (PAD) (B -0.96, 95% CI -1.47 ~ -0.46, p < 0.001). This evidence concerns the gene INS and peripheral arterial disease.