Consistent with the results in 85As2 cell cultures, plasma LIF levels increased in 85As2-bearing rats with the development of cachexia symptoms, and surgical removal of the tumor not only abolished cachexia symptoms but also reduced plasma LIF levels to below the detection limit, demonstrating that LIF contributes to cachexia symptoms in the 85As2-induced CC model [10]. This evidence concerns the gene LIF and Cachexia.