In 85As2-bearing CC rats (85As2 + DW), 22-h food intake following i.p. injection of both vehicle and ghrelin was significantly decreased compared to that in non-tumor-bearing rats (22-h food intake following vehicle injection: Control + DW, 21.28 ± 1.13 g; 85As2 + DW, 14.33 ± 1.19 g; 22-h food intake following ghrelin injection: Control + DW, 21.61 ± 0.82 g; 85As2 + DW, 14.78 ± 1.25 g, two-way repeated measures ANOVA followed by Bonferroni post-hoc tests, p < 0.01, p < 0.05, respectively; Fig 5B). Here, GHRL is linked to neoplasm.