More recent studies including larger series of patients have identified HLA-A*02:01, HLA-DRB4*01:01, as well as the haplotypes DRB4*01:01-DRB1*07:01-DQB1*03:03 and HLA-A*01-B*08-C*07 as being factors related to CLL predisposition [24, 26]. Here, HLA-A is linked to B-cell chronic lymphocytic leukemia.