Allele frequencies differed significantly between pMBL/CLL and healthy control individuals, whereby we found a higher frequency of HLA-A*11 (14% vs. 7%, P<0.001, Pc = 0.008), HLA-DRB1*03 (18% vs. 12%, P = 0.019, Pc = 0.180), and HLA-DQB1*02 (33% vs. 27%, P = 0.029, Pc = 0.150), and a lower frequency of HLA-B*44 (10% vs. 16%, P = 0.008, Pc = 0.230) in pMBL/CLL than in healthy controls. This evidence concerns the gene HLA-B and B-cell chronic lymphocytic leukemia.