We used Genomic Regions Enrichment of Annotations Tool (GREAT) [72] to identify genes associated with TFAP2A peaks in mouse and human melanocytes, with an assignment rule of basal promoter plus 100kb distal, and found that these genes are enriched for ontology terms relevant to melanocyte differentiation, including “pigmentation”, “melanosome”, and “melanoma” (S6A and S6B Fig). The gene discussed is TFAP2A; the disease is melanoma.