It is conceivable, however, that the documented stabilization of p53 might be due to an aberrant posttranslational modification, which is known to suppress p53 functional activities, including growth arrest and transcriptional activation of target genes [46], as the stabilization of p53 is depicted in actively invading tumor cells (Fig 6B and 6C digital inserts). This evidence concerns the gene TP53 and neoplasm.