However we looked at the RNA expression level of BET genes (BRD2, BRD3 and BRD4) in alveolar macrophages from six COPD patients and in whole blood from the ECLIPSE COPD patients (S4 Appendix: Expression of BET genes in COPD donors from the ECLIPSE studies). The gene discussed is BRD2; the disease is chronic obstructive pulmonary disease.