In these experiments AM derived from COPD patients were stimulated with LPS in the presence or absence of JQ1 for 6hrs as described above and change in expression of 8 out of 10 signature genes (XAF1 and OAS2 were not analyzed for technical reasons) and 4 cytokines was analyzed by RT-PCR (Fig 7). This evidence concerns the gene XAF1 and chronic obstructive pulmonary disease.