To increase our understanding of the genes regulated by the pan-BET inhibitor JQ1 and thus associated with histone hyperacetylation in COPD lung derived inflammatory cells, we performed a global gene expression approach on LPS stimulated alveolar macrophages from six COPD donors, and looked at the impact on gene expression of JQ1 treatment. The gene discussed is DNER; the disease is chronic obstructive pulmonary disease.