IL6 and chronic obstructive pulmonary disease: However, the IL-6 response was effectively inhibited following JQ1 treatment only in AM and PBMCs from COPD patients with approximately 50% inhibition and 25% inhibition at 1μM in alveolar macrophages and PBMC from COPD patients, respectively, whereas no inhibition was seen in PMBC from normal controls (Fig 5D).