TGM2 and type 2 diabetes mellitus: It is important to note that TGM2, TGM3, and TGM7 nsSNVs do not seem to be associated with any pathological phenotype except perhaps TGM2 heterozygous mutations associated with early-onset type 2 diabetes, an observation which has not been confirmed in animal experiments and large clinical cohorts [6, 47, 48, 79].