The functions of the genes associated with the trans-acting GWAS SNPs highlighted their role in T1D (Ingenuity pathway analysis, P = 4.39x10-5, Fig 3A) and mTOR signaling (P = 3.84x10-3, Fig 3A) in CD4+ and CD8+ T cells, respectively. This evidence concerns the gene CD4 and type 1 diabetes mellitus.