USP18 and neoplasm: Multigene expression analysis by qRT–PCR revealed a strong correlation between the expression of human monocytic markers CD14 or CD16 and diverse IFN-I-related genes such as IFNB1, USP18 and IRF7 (Supplementary Fig. 7a,b), indicating that human monocytic infiltrates can produce IFN-I within human tumour tissues.