These genes included Elovl4, Abhd5, Cers3, Cyp4f39 (a mouse ortholog of human CYP4F22), Ugcg, Abca12 and Gba, mutation or deletion of which has been shown to cause ARCI in humans and neonatal death in mice due to severe skin barrier defects1, 41. Here, CYP4F22 is linked to autosomal recessive congenital ichthyosis.