Recent studies of patients with neutral lipid storage disease with ichthyosis (NLSDI or Chanarin-Dorfman syndrome) and in mice with Abhd5 deletion suggest that TG accumulation due to loss-of-function of ABHD5 (also known as CGI-58) reduces the availability of LA for acylceramide production22, 23. This evidence concerns the gene ABHD5 and ichthyosis.