To gain further insight into the clonal dynamics of the IFE and the HF-derived SCs populations, we used a previously validated biostatistical framework59, 60, 61 to infer with high confidence the number of cells and cellular composition of clones (basal versus suprabasal cells) arising from single K14 and Lrig1CREER/Rosa Confetti-targeted cells (Fig. 8a–e; Supplementary Note 1). Here, KRT14 is linked to hydrops fetalis.