Importantly, the simultaneous pathoproteomic evaluation of dystrophin and downstream changes in the mdx-4cv mouse model of Duchenne muscular dystrophy revealed considerable increases in markers of myofibrosis, such as collagens, fibronectin, biglycan, asporin, decorin, prolargin, mimecan, and lumican. This evidence concerns the gene DMD and Duchenne muscular dystrophy.