DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Importantly, since skeletal muscles from this animal model of dystrophinopathy are characterized by very few revertant fibers and exhibit myofibrosis [50,51,52,53], the proteomic analysis of total mdx-4cv muscle extracts was ideally suited to simultaneously study dystrophin deficiency and secondary fibrotic changes within the same analytical run.