Importantly, the simultaneous pathoproteomic evaluation of dystrophin and downstream changes in the mdx-4cv mouse model of Duchenne muscular dystrophy revealed considerable increases in markers of myofibrosis, such as collagens, fibronectin, biglycan, asporin, decorin, prolargin, mimecan, and lumican. The gene discussed is DCN; the disease is Duchenne muscular dystrophy.