MAPK1 and cancer: Figure 6A shows some examples of inhibited signaling cascades related to cancer cell growth and survival, including signaling through Ras-Raf-Mek-Erk pathways, PI3K signaling, β-catenin signaling, and apoptosis pathways. Similar negative effects on signaling can also be visualized using IPA software for adherens junction signaling, integrin signaling, HGF signaling, and Paxillin signaling, among others (Supplemental IPA Data).