Upregulated proteins in Daoy included several proteins involved in signal transduction (EGFR, CRK), cell adhesion (JUP, TGFBI), tumor invasion and metastasis (TNC), stress resistance (HSP90AA1, HSP90AB1) and DNA binding/repair (TOP2A, MSH2 and MSH6). The gene discussed is TGFBI; the disease is neoplasm.